By the way, don't just think about the first Switcheroo. If you start with an Iron Orb and switch it onto a Specsmence, you can then switch-out Lopunny for later and then Switcheroo the Specs onto something like a Ninjask or Bulky Gyara.
Lopunny @ Iron Orb
Stats: 252 Speed, rest split between HP and Atk | Jolly
Klutz
----------
Fake Out
Switcheroo
Sky Uppercut/Fire Punch/Thunderpunch/Ice Punch
Healing Wish
Fake Out for free damage, Switcheroo is obvious, an attack to counter whatever your team is weak against, and Healing Wish to re-use something else once Lopunny has done it's damage.
You make me feel so silly. I hadn't even considered the possibility of reswitching their items altogether! Specs on Hera or Weavile would be so satisfying (even an Iron Orb on Weavile...mwahahah). I think I'm taking Ice Punch since no one else has an Ice or Dragon move to cover Mence et al. Sky Uppercut would be nice to have as another Dark counter, though.
As far as EVs go, I think I'll run 128 HP, 128 Atk, 252 Spd. Basic, yes, but I think that should balance out. If there is a more specific spread that I should use, let me know. I'm not so good at making EV spreads, but at least I came up with something.
Question about the chain, though: how would I get Fake Out, Ice Punch/Sky Uppercut
and Switcheroo all on the same Lopunny? Tyrogue/Hitmonchan gets Fake Out and IP/SU; Persian gets Fake Out and Switcheroo; Hypno gets IP and Switcheroo. I can't seem to find a workable chain! =/